Products

Western Blot (Tissue lysate)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

STRADA

Gene Alias

FLJ90524, LYK5, NY-BR-96, PMSE, STRAD, Stlk

Gene Description

STE20-related kinase adaptor alpha

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq

Other Designations

STE20-like pseudokinase|STE20-related adaptor protein|protein kinase LYK5