NALP12 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human NALP12 partial ORF ( AAH28069, 1 a.a. - 110 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Interspecies Antigen Sequence
Mouse (70); Rat (72)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — NLRP12
Entrez GeneID
91662GeneBank Accession#
BC028069Protein Accession#
AAH28069Gene Name
NLRP12
Gene Alias
CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2
Gene Description
NLR family, pyrin domain containing 12
Omim ID
609648Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined. [provided by RefSeq
Other Designations
NACHT, LRR and PYD containing protein 12|NACHT, leucine rich repeat and PYD containing 12|OTTHUMP00000067226|PYRIN-containing APAF1-like protein 7|monarch 1|nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12|regu
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Interactome
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Disease
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