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SIGLEC12 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00089858-T01
  • Visit Frequency :
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-SIGLEC12 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 65.56
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-SIGLEC12 antibody (H00089858-B01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00089858-T01
    SIGLEC12 transfected lysate.
    Western Blot
    QC Testing of H00089858-T01
    Lane 1: SIGLEC12 transfected lysate ( 65.56 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Gene Name:
  • SIGLEC12
  • Gene Alias:
  • FLJ38600,S2V,SIGLECL1,SLG,Siglec-12,Siglec-L1,Siglec-XII
  • Gene Description:
  • sialic acid binding Ig-like lectin 12
  • Gene Summary:
  • Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq
  • Other Designations:
  • SIGLEC-like 1,sialic acid binding immunoglobulin-like lectin-like protein 1
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