WNT3A (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human WNT3A full-length ORF ( AAI03922.1, 1 a.a. - 385 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCKNPGSRAGNSAHQPPHPQPPVRFHPPLRRAGKVP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
69.3
Interspecies Antigen Sequence
Mouse (96); Rat (95)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — WNT3A
Entrez GeneID
89780GeneBank Accession#
BC103921.1Protein Accession#
AAI03922.1Gene Name
WNT3A
Gene Alias
MGC119418, MGC119419, MGC119420
Gene Description
wingless-type MMTV integration site family, member 3A
Omim ID
606359Gene Ontology
HyperlinkGene Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq
Other Designations
OTTHUMP00000035713
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Interactome
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Pathway
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Disease
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Publication Reference
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Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck.
Jing Q, Li G, Chen X, Liu C, Lu S, Zheng H, Ma H, Qin Y, Zhang D, Zhang S, Ren S, Huang D, Tan P, Chen J, Qiu Y, Liu Y.
Journal of Cellular and Molecular Medicine 2019 Jul; 23(7):4711.
Application：Func, Human, 6-10B, SCCHN Tu686 cells.
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Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas.
Zhang KL, Han L, Chen LY, Shi ZD, Yang M, Ren Y, Chen LC, Zhang JX, Pu PY, Kang CS.
Cancer Letters 2014 Jan; 342(1):139.
Application：WB-Ce, Human, U87, LN229 cells.
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Wnt3a promotes radioresistance via autophagy in squamous cell carcinoma of the head and neck.
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