MICAL-L1 purified MaxPab mouse polyclonal antibody (B01P)
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human MICAL-L1 protein.
Immunogen
MICAL-L1 (AAI48805.1, 1 a.a. ~ 863 a.a) full-length human protein.
Sequence
MAGPRGALLAWCRRQCEGYRGVEIRDLSSSFRDGLAFCAILHRHRPDLLDFDSLSKDNVFENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFCSPGQAGVSPPRKGLAPCSPPSVAPTPVEPEDVAQGEELSSGSLSEQGTGQTPSSTCAACQQHVHLVQRYLADGRLYHRHCFRCRRCSSTLLPGAYENGPEEGTFVCAEHCARLGPGTRSGTRPGPFSQPKQQHQQQLAEDAKDVPGGGPSSSAPAGAEADGPKASPEARPQIPTKPRVPGKLQELASPPAGRPTPAPRKASESTTPAPPTPRPRSSLQQENLVEQAGSSSLVNGRLHELPVPKPRGTPKPSEGTPAPRKDPPWITLVQAEPKKKPAPLPPSSSPGPPSQDSRQVENGGTEEVAQPSPTASLESKPYNPFEEEEEDKEEEAPAAPSLATSPALGHPESTPKSLHPWYGITPTSSPKTKKRPAPRAPSASPLALHASRLSHSEPPSATPSPALSVESLSSESASQTAGAELLEPPAVPKSSSEPAVHAPGTPGNPVSLSTNSSLASSGELVEPRVEQMPQASPGLAPRTRGSSGPQPAKPCSGATPTPLLLVGDRSPVPSPGSSSPQLQVKSSCKENPFNRKPSPAASPATKKATKGSKPVRPPAPGHGFPLIKRKVQADQYIPEEDIHGEMDTIERRLDALEHRGVLLEEKLRGGLNEGREDDMLVDWFKLIHEKHLLVRRESELIYVFKQQNLEQRQADVEYELRCLLNKPEKDWTEEDRAREKVLMQELVTLIEQRNAIINCLDEDRQREEEEDKMLEAMIKKKEFQREAEPEGKKKGKFKTMKMLKLLGNKRDAKSKSPRDKS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (77); Rat (77)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
MICALL1 MaxPab polyclonal antibody. Western Blot analysis of MICALL1 expression in HepG2.Western Blot (Transfected lysate)
Western Blot analysis of MICALL1 expression in transfected 293T cell line (H00085377-T01) by MICALL1 MaxPab polyclonal antibody.
Lane 1: MICAL-L1 transfected lysate(94.93 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — MICALL1
Entrez GeneID
85377GeneBank Accession#
BC148804Protein Accession#
AAI48805.1Gene Name
MICALL1
Gene Alias
DKFZp686M2226, FLJ45921, KIAA1668, MICAL-L1, MIRAB13
Gene Description
MICAL-like 1
Gene Ontology
HyperlinkOther Designations
molecule interacting with Rab13
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Interactome
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Publication Reference
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Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome.
Bali Lee, Christopher Hoyle, Rose Wellens, Jack P Green, Fatima Martin-Sanchez, Daniel M Williams, Billie J Matchett, Paula I Seoane, Hayley Bennett, Antony Adamson, Gloria Lopez-Castejon, Martin Lowe, David Brough.
Science Signaling 2023 Feb; 16(773):eabm7134.
Application:IF, African Green Monkey , COS7 cells.
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Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.
Adamantios Mamais, Jillian H. Kluss, Luis Bonet-Ponce, Natalie Landeck, Rebekah G. Langston, Nathan Smith, Alexandra Beilina, Alice Kaganovich, Manik C. Ghosh, Laura Pellegrini, Ravindran Kumaran, Ioannis Papazoglou, George R. Heaton, Rina Bandopadhyay, Nunziata Maio, Changyoun Kim, Matthew J. LaVoie, David C. Gershlick, Mark R. Cookson.
PLoS Biology 2021 Dec; 19(12):e3001480.
Application:WB-Ce, Human, HEK293T cells.
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Defining the protein and lipid constituents of tubular recycling endosomes.
Trey Farmer, Shuwei Xie, Naava Naslavsky, Jacqueline Stöckli, David E James, Steve Caplan.
The Journal of Biological Chemistry 2020 Dec; 296:100190.
Application:IF, Human, Mouse, HeLa cells, MEFs.
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Rab10 regulates tubular endosome formation through KIF13A/B motors.
Etoh K, Fukuda M.
Journal of Cell Science 2019 Feb; 132(5): jcs226977.
Application:IF, WB, Human , HeLa cells.
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Diacylglycerol kinase α regulates tubular recycling endosome biogenesis and major histocompatibility complex class I recycling.
Xie S, Naslavsky N, Caplan S.
The Journal of Biological Chemistry 2014 Nov; 289(46):31914.
Application:IF, IP-WB, WB-Tr, Human, HeLa cells.
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Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth.
Kobayashi H, Etoh K, Ohbayashi N, Fukuda M.
Biology Open 2014 Aug; 3(9):803.
Application:IF, WB-Tr, Rat, PC12 cells.
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Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth.
Kobayashi H, Fukuda M.
Journal of Cell Science 2013 Jun; 126(Pt 11):2424.
Application:IF, WB-Tr, Mouse, PC-12 cells.
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MICAL-L1 Links EHD1 to Tubular Recycling Endosomes and Regulates Receptor Recycling.
Sharma M, Giridharan SS, Rahajeng J, Naslavsky N, Caplan S.
Molecular Biology of the Cell 2009 Dec; 20(24):5181.
Application:IF, WB-Tr, Human, HeLa cells.
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Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome.
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