Western blot analysis of TNFRSF19L over-expressed 293 cell line, cotransfected with TNFRSF19L Validated Chimera RNAi ( Cat # H00084957-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with TNFRSF19L monoclonal antibody (M01), clone 3F8 (Cat # H00084957-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. [provided by RefSeq
receptor expressed in lymphoid tissues,tumor necrosis factor receptor superfamily, member 19-like