TNS4 monoclonal antibody (M01), clone 3B8
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant TNS4.
Immunogen
TNS4 (AAH18706, 1 a.a. ~ 480 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (80); Rat (74)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (78.54 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of TNS4 expression in transfected 293T cell line by TNS4 monoclonal antibody (M01), clone 3B8.
Lane 1: TNS4 transfected lysate(51.8 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TNS4 is approximately 0.1ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to TNS4 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — TNS4
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Interactome
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Disease
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Publication Reference
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Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression.
Haejeong Heo, Hee-Jin Kim, Keeok Haam, Hyun Ahm Sohn, Yang-Ji Shin, Hanyong Go, Hyo-Jung Jung, Jong-Hwan Kim, Sang-Il Lee, Kyu-Sang Song, Min-Ju Kim, Haeseung Lee, Eun-Soo Kwon, Seon-Young Kim, Yong Sung Kim, Mirang Kim.
Molecules and Cells 2023 May; 46(5):298.
Application:IHC, WB, Human, Gastric tumors, Kato, MNK74, SNu-601 cells.
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Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors.
Lyugao Qin, Xuan Cao, Tomonori Kaneko, Courtney Voss, Xuguang Liu, Guoping Wang, Shawn S-C Li.
The Journal of Biological Chemistry 2021 Sep; 297(4):101161.
Application:WB-Ce, Human, MCF-10A.
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Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration.
McHugh BJ, Murdoch A, Haslett C, Sethi T.
PLoS One 2012 Jul; 7(7):e40346.
Application:IF, Human, 16HBE cells.
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Prognostic Relevance of Tensin4 Expression in Human Gastric Cancer.
Sakashita K, Mimori K, Tanaka F, Kamohara Y, Inoue H, Sawada T, Hirakawa K, Mori M.
Annals of Surgical Oncology 2008 Jul; 15(9):2606.
Application:IHC-P, WB-Ti, Human, Human gastric cancer.
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Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression.
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