HSH2D (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human HSH2D full-length ORF ( AAH25237, 1 a.a. - 352 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MTEAGKLPLPLPPRLDWFVHTQMGQLAQDGVPEWFHGAISREDAENLLESQPLGSFLIRVSHSHVGYTLSYKAQSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPCRQKDPANVDYEDLFLYSNAVAEEAACPVSAPEEASPKPVLCHQSKERKPSAEMNRITTKEATSSCPPKSPLGETRQKLWRSLKMLPERGQRVRQQLKSHLATVNLSSLLDVRRSTVISGPGTGKGSQDHSGDPTSGDRGYTDPCVATSLKSPSQPQAPKDRKVPTRKAERSVSCIEVTPGDRSWHQMVVRALSSQESKPEHQGLAEPENDQLPEEYQQPPPFAPGYC
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
64.46
Interspecies Antigen Sequence
Mouse (52); Rat (51)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — HSH2D
Entrez GeneID
84941GeneBank Accession#
BC025237Protein Accession#
AAH25237Gene Name
HSH2D
Gene Alias
ALX, FLJ14886, HSH2
Gene Description
hematopoietic SH2 domain containing
Omim ID
608349Gene Ontology
HyperlinkGene Summary
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM
Other Designations
adaptor in lymphocytes of unknown function X|hematopoietic SH2 protein
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Interactome
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Disease
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