SETDB2 monoclonal antibody (M17), clone 2F4
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant SETDB2.
Immunogen
SETDB2 (NP_114121.1, 451 a.a. ~ 550 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
HPRTAKTEKCPPKFSNNPKELTMETKYDNISRIQYHSVIRDPESKTAIFQHNGKKMEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDSSSNHVDEFED
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
SETDB2 monoclonal antibody (M17), clone 2F4. Western Blot analysis of SETDB2 expression in A-431(Cat # L015V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — SETDB2
Entrez GeneID
83852GeneBank Accession#
NM_031915Protein Accession#
NP_114121.1Gene Name
SETDB2
Gene Alias
C13orf4, CLLD8, CLLL8, DKFZp586I0123, DKFZp761J1217, KMT1F
Gene Description
SET domain, bifurcated 2
Omim ID
607865Gene Ontology
HyperlinkGene Summary
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM
Other Designations
CLLL8 protein|OTTHUMP00000018417
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Interactome
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Pathway
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Disease
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Publication Reference
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SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression.
Lin CH, Wong SH, Kurzer JH, Schneidawind C, Wei MC, Duque-Afonso J, Jeong J, Feng X, Cleary ML.
Cell Reports 2018 Apr; 23(4):1166.
Application:ChIP, WB, Human, RCH-ACV, 697 cells.
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SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression.
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