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ITCH Pre-design Chimera RNAi

  • Catalog # : H00083737-R01
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Homo sapiens itchy homolog E3 ubiquitin protein ligase (mouse) (ITCH), mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_031483
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Gene Name:
  • ITCH
  • Gene Alias:
  • AIF4,AIP4,NAPP1,dJ468O1.1
  • Gene Description:
  • itchy E3 ubiquitin protein ligase homolog (mouse)
  • Gene Summary:
  • Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq
  • Other Designations:
  • NFE2-associated polypeptide 1,atrophin-1 interacting protein 4,dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4)),itchy homolog E3 ubiquitin protein ligase,ubiquitin protein ligase ITCH
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