SPACA1 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human SPACA1 DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — SPACA1
Entrez GeneID
81833GeneBank Accession#
NM_030960.2Protein Accession#
NP_112222.1Gene Name
SPACA1
Gene Alias
MGC32952, SAMP32
Gene Description
sperm acrosome associated 1
Gene Ontology
HyperlinkGene Summary
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq
Other Designations
OTTHUMP00000016837|sperm acrosomal membrane-associated protein 32
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Interactome
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Disease
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