COASY monoclonal antibody (M05), clone 2A12
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant COASY.
Immunogen
COASY (NP_079509, 461 a.a. ~ 564 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AEGKRVCVIDAAVLLEAGWQNLVHEVWTAVIPETEAVRRIVERDGLSEAAAQSRLQSQMSGQQLVEQSHVVLSTLWEPHITQRQVEKAWALLQKRIPKTHQALD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (85)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.18 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to COASY on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged COASY is approximately 1ng/ml as a capture antibody.ELISA
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Gene Info — COASY
Entrez GeneID
80347GeneBank Accession#
NM_025233Protein Accession#
NP_079509Gene Name
COASY
Gene Alias
DPCK, FLJ35179, NBP, PPAT, UKR1, pOV-2
Gene Description
Coenzyme A synthase
Omim ID
609855Gene Ontology
HyperlinkGene Summary
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. COASY is a bifunctional enzyme that catalyzes the 2 last steps in CoA synthesis. These activities are performed by 2 separate enzymes, phosphopantetheine adenylyltransferase (PPAT; EC 2.7.7.3) and dephospho-CoA kinase (DPCK; EC 2.7.1.24), in prokaryotes (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM
Other Designations
bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase|coenzyme A synthase|nucleotide binding protein|phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase
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Interactome
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Pathway
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Disease
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