EDEM3 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human EDEM3 peptide using ARM Technology.
Immunogen
A synthetic peptide of human EDEM3 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human EDEM3 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — EDEM3
Entrez GeneID
80267GeneBank Accession#
EDEM3Gene Name
EDEM3
Gene Alias
C1orf22
Gene Description
ER degradation enhancer, mannosidase alpha-like 3
Omim ID
610214Gene Ontology
HyperlinkGene Summary
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM
Other Designations
ER degradation-enhancing -mannosidase-like protein 3
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Interactome
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