SLC24A6 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human SLC24A6 full-length ORF ( NP_079235.2, 1 a.a. - 584 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
90.6
Interspecies Antigen Sequence
Mouse (83); Rat (82)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — SLC24A6
Entrez GeneID
80024GeneBank Accession#
NM_024959.2Protein Accession#
NP_079235.2Gene Name
SLC24A6
Gene Alias
FLJ22233, NCKX6, NCLX
Gene Description
solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
Omim ID
609841Gene Ontology
HyperlinkGene Summary
SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM
Other Designations
sodium/potassium/calcium exchanger|solute carrier family 24 member 6
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Publication Reference
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Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca 2+ release in cancer cells.
Vidhya Tangeda, Yu Kang Lo, Ananth Ponneri Babuharisankar, Han-Yu Chou, Cheng-Liang Kuo, Yung-Hsi Kao, Alan Yueh-Luen Lee, Jang-Yang Chang.
Cell Death & Disease 2022 Mar; 13(3):241.
Application:Pull-Down, Human, OEC-M1 cells.
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Lon upregulation contributes to cisplatin resistance by triggering NCLX-mediated mitochondrial Ca 2+ release in cancer cells.
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