E2F8 monoclonal antibody (M01), clone 3E9-2F5
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More Files
- More Functions
Western Blot detection against Immunogen (73.15 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant FLJ23311.
Immunogen
E2F8 (AAH28244, 1 a.a. ~ 431 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MAQLAAICKMQLEEQSSESRQKVKVQLARSGPCKPVAPLDPPVNAEMELTAPSLIQPLGMVPLIPSPLSSAVPLILPQAPSGPSYAIYLQPTQAHQSVTPPQGLSPTVCTTHSSKATGSKDSTDATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAGERGSKRASMLEDSGSKKKFKEDLKGLENVSATLFPSGYLIPLTQCSSLGAESILSGKENSSALSPNHRIYSSPIAGVIPVTSSELTAVNFPSFHVTPLKLMVSPTSVAAVPVGNSPALASSHPVPIQNPSSAIVNFTLQHLGLISPNVQLSASPGSGIVPVSPRIESVNVAPENAGTQQGRATNYDSPVPGQSQPNGQSVAVTGAQQPVPVTPKGSQLVAESFFRTPGGPTKPTSSSCMDFEGANKTSLGTLFVPQRKLEVSTEDVH
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (82); Rat (82)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (73.15 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — E2F8
Entrez GeneID
79733GeneBank Accession#
BC028244Protein Accession#
AAH28244Gene Name
E2F8
Gene Alias
FLJ23311
Gene Description
E2F transcription factor 8
Gene Ontology
HyperlinkGene Summary
E2F transcription factors, such as E2F8, are essential for orchestrating expression of genes required for cell cycle progression and proliferation (Christensen et al., 2005 [PubMed 16179649]).[supplied by OMIM
Other Designations
E2F family member 8
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Interactome
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Publication Reference
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Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo.
de Bruin A, A Cornelissen PW, Kirchmaier BC, Mokry M, Iich E, Nirmala E, Liang KH, D Végh AM, Scholman KT, Groot Koerkamp MJ, Holstege FC, Cuppen E, Schulte-Merker S, Bakker WJ.
Nucleic Acids Research 2016 May; 44(8):3549.
Application：WB-Tr, Human, HeLa cells.
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E2F8 Contributes to Human Hepatocellular Carcinoma via Regulating Cell Proliferation.
Deng Q, Wang Q, Zong WY, Zheng DL, Wen YX, Wang KS, Teng XM, Zhang X, Huang J, Han ZG.
Cancer Research 2010 Jan; 70(2):782.
Application：ChIP, IF, IHC, WB-Tr, Human, HepG2 Huh-7, PLC/PRF/5, YY8103 cells, Human hepatocellular carcinoma, Human tissue array.
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DNA-damage response control of E2F7 and E2F8.
Panagiotis Zalmas L, Zhao X, Graham AL, Fisher R, Reilly C, Coutts AS, La Thangue NB.
EMBO reports 2008 Jan; 9(3):252.
Application：WB, Human, Mouse, Hct15, Hct116, HeLa, MCF7, MEF, T98G, U2OS cells.
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Synergistic Function of E2F7 and E2F8 Is Essential for Cell Survival and Embryonic Development.
Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A.
Developmental Cell 2008 Jan; 14(1):62.
Application：WB, Human, HeLa cells.
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Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo.
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