RNASEH2B (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human RNASEH2B full-length ORF ( AAH36744.1, 1 a.a. - 331 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAAGVDCGDGVGARQHVFLVSEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLLHYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSRVQSTAFFSGDQASTDKEKDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKKNSKMTAAQKALAKVDKSGMKSIDTFFGVKKKLERFETLKIKSSKNICFLHVSVCPS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
63.8
Interspecies Antigen Sequence
Mouse (80); Rat (80)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — RNASEH2B
Entrez GeneID
79621GeneBank Accession#
BC036744.1Protein Accession#
AAH36744.1Gene Name
RNASEH2B
Gene Alias
AGS2, DLEU8, FLJ11712
Gene Description
ribonuclease H2, subunit B
Omim ID
610326Gene Ontology
HyperlinkGene Summary
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq
Other Designations
Aicardi-Goutieres syndrome 2 protein|OTTHUMP00000018436|OTTHUMP00000040890|RNase H2 subunit B|deleted in leukemia 8 protein|deleted in lymphocytic leukemia 8
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Interactome
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Pathway
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