FYCO1 polyclonal antibody (A01)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of FYCO1 expression in transfected 293T cell line by FYCO1 polyclonal antibody (A01).
Lane1:FYCO1 transfected lysate (Predicted MW: 29.2 KDa).
Lane2:Non-transfected lysate.
Western Blot detection against Immunogen (54.16 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length recombinant FYCO1.
Immunogen
FYCO1 (AAH07218, 1 a.a. ~ 255 a.a) full-length recombinant protein with GST tag.
Sequence
MNTKVTSDWYYARSPFLQPKLSSDIVGQLYELTEVQFDLASRGFDLDAAWPTFARRTLTTGSSAYLWKPPSRSSSMSSLVSSYLQTQEMVSNFDLNSPLNNEALEGFDEMRLELDQLEVREKQLQERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNVRLTCLVAELQKQWEVTQATQNTVKELQTCLQALELGAAEKEEDYHTALRRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMALHVGD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (72); Rat (73)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (54.16 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of FYCO1 expression in transfected 293T cell line by FYCO1 polyclonal antibody (A01).
Lane1:FYCO1 transfected lysate (Predicted MW: 29.2 KDa).
Lane2:Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — FYCO1
Entrez GeneID
79443GeneBank Accession#
BC007218Protein Accession#
AAH07218Gene Name
FYCO1
Gene Alias
DKFZp779K1152, FLJ13335, MGC126517, MGC126519, RUFY3, ZFYVE7
Gene Description
FYVE and coiled-coil domain containing 1
Omim ID
607182Gene Ontology
HyperlinkOther Designations
OTTHUMP00000164650|RUN and FYVE domain containing 3
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Interactome
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Disease
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Publication Reference
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Protrudin-mediated ER-endosome contact sites promote phagocytosis.
Liv Anker Elfmark, Eva Maria Wenzel, Ling Wang, Nina Marie Pedersen, Harald Stenmark, Camilla Raiborg.
Cellular and Molecular Life Sciences : CMLS 2023 Jul; 80(8):216.
Application：IF, Human, RPE1 cells.
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Loss of FYCO1 leads to cataract formation.
Kiyotoshi Satoh, Yukitoshi Takemura, Motohiko Satoh, Kiyokazu Ozaki, Shunichiro Kubota.
Scientific Reports 2021 Jul; 11(1):13771.
Application：WB-Ce, WB-Ti, WB-Tr, Mouse, MEFs, Mouse brain, Mouse eye, Mouse heart, Mouse liver, Mouse lung, Mouse skeletal muscle, Mouse spleen.
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Protrudin-mediated ER-endosome Contact Sites Promote MT1-MMP Exocytosis and Cell Invasion.
Nina Marie Pedersen, Eva Maria Wenzel, Ling Wang, Sandra Antoine, Philippe Chavrier, Harald Stenmark, Camilla Raiborg.
The Journal of Cell Biology 2020 Aug; 219(8):e202003063.
Application：IF, WB-Tr, Human, MDA-MB-231 cells.
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PtdIns3P controls mTORC1 signaling through lysosomal positioning.
Hong Z, Pedersen NM, Wang L, Torgersen ML, Stenmark H, Raiborg C.
Journal of Cellular Biology 2017 Oct; 216(12):4217.
Application：IF, WB-Ce, Human, HeLa cells.
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FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.
Pankiv S, Alemu EA, Brech A, Bruun JA, Lamark T, Overvatn A, Bjorkoy G, Johansen T.
The Journal of Cell Biology 2010 Jan; 188(2):253.
Application：IF, WB-Tr, Human, HeLa cells, Mouse embryonic fibroblasts.
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Protrudin-mediated ER-endosome contact sites promote phagocytosis.
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