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Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

CARD14

Gene Alias

BIMP2, CARMA2

Gene Description

caspase recruitment domain family, member 14

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq

Other Designations

CARD-containing MAGUK 2 protein|bcl10-interacting maguk protein 2|card-maguk protein 2|caspase recruitment domain protein 14