CARD14 monoclonal antibody (M01), clone 4B3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CARD14.
Immunogen
CARD14 (NP_077015, 905 a.a. ~ 1004 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VQLDSVCTLHRMDIFPIVIHVSVNEKMAKKLKKGLQRLGTSEEQLLEAARQEEGDLDRAPCLYSSLAPDGWSDLDGLLSCVRQAIADEQKKVVWTEQSPR
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (73)
Isotype
IgG2b Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CARD14 is approximately 0.1ng/ml as a capture antibody.ELISA
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Gene Info — CARD14
Entrez GeneID
79092GeneBank Accession#
NM_024110Protein Accession#
NP_077015Gene Name
CARD14
Gene Alias
BIMP2, CARMA2
Gene Description
caspase recruitment domain family, member 14
Omim ID
607211Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
CARD-containing MAGUK 2 protein|bcl10-interacting maguk protein 2|card-maguk protein 2|caspase recruitment domain protein 14
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Interactome
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Disease
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