FTO rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human FTO peptide using ARM Technology.
Immunogen
A synthetic peptide of human FTO is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human FTO peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — FTO
Entrez GeneID
79068GeneBank Accession#
FTOGene Name
FTO
Gene Alias
KIAA1752, MGC5149
Gene Description
fat mass and obesity associated
Gene Ontology
HyperlinkGene Summary
The exact function of this gene is not know. Studies in mice suggest that it may be involved in nucleic acid demethylation, and that its mRNA level is regulated by feeding and fasting. Genomewide association studies of type 2 diabetes indicate this gene as a diabetes susceptibility locus. Mutation in this gene has been associated with growth retardation, developmental delay, coarse facies, and early death. [provided by RefSeq
Other Designations
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Interactome
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Disease
- Anorexia Nervosa
- Appetite
- Asthma
- Atherosclerosis
- Birth Weight
- Calcinosis
- Carcinoma
- Cardiovascular Diseases
- Cataract
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