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Last updated: 2016/12/4

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UPF3B Pre-design Chimera RNAi

  • Catalog # : H00065109-R01
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  • Specification
  • Product Description:
  • Homo sapiens zinc finger protein 406 antisense transcript (SAS-ZFAT) on chromosome 8.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_023010
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.
    The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Gene Name:
  • UPF3B
  • Gene Alias:
  • HUPF3B,MRXS14,RENT3B,UPF3X
  • Gene Description:
  • UPF3 regulator of nonsense transcripts homolog B (yeast)
  • Gene Summary:
  • This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000023923,OTTHUMP00000023924,UPF3 regulator of nonsense transcripts homolog B
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