TMPRSS3 monoclonal antibody (M01), clone 2E1
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant TMPRSS3.
Immunogen
TMPRSS3 (NP_076927, 119 a.a. ~ 214 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYS
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.67 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — TMPRSS3
Entrez GeneID
64699GeneBank Accession#
NM_024022Protein Accession#
NP_076927Gene Name
TMPRSS3
Gene Alias
DFNB10, DFNB8, ECHOS1, TADG12
Gene Description
transmembrane protease, serine 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq
Other Designations
OTTHUMP00000109345|serine protease TADG12
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Interactome
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Disease
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Publication Reference
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A novel genome-based approach correlates TMPRSS3 overexpression in ovarian cancer with DNA hypomethylation.
Guerrero K, Wang Z, Bachvarova M, Gregoire J, Renaud MC, Plante M, Bachvarov D.
Gynecologic Oncology 2012 Jun; 125(3):720.
Application:WB-Ce, Human, SKOV3, OVCAR3 cells.
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A novel genome-based approach correlates TMPRSS3 overexpression in ovarian cancer with DNA hypomethylation.
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