GREM2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human GREM2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human GREM2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human GREM2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — GREM2
Entrez GeneID
64388GeneBank Accession#
GREM2Gene Name
GREM2
Gene Alias
CKTSF1B2, DAND3, PRDC
Gene Description
gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)
Omim ID
608832Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq
Other Designations
OTTHUMP00000037834|cysteine knot superfamily 1, BMP antagonist 2|gremlin 2|protein related to DAN and cerberus
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