Immunoprecipitation of GREM2 transfected lysate using anti-GREM2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with GREM2 purified MaxPab mouse polyclonal antibody (B01P) (H00064388-B01P).
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq
OTTHUMP00000037834,cysteine knot superfamily 1, BMP antagonist 2,gremlin 2,protein related to DAN and cerberus