NFKBIZ rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human NFKBIZ peptide using ARM Technology.
Immunogen
A synthetic peptide of human NFKBIZ is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human NFKBIZ peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — NFKBIZ
Entrez GeneID
64332GeneBank Accession#
NFKBIZGene Name
NFKBIZ
Gene Alias
FLJ30225, FLJ34463, IKBZ, INAP, MAIL
Gene Description
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Omim ID
608004Gene Ontology
HyperlinkGene Summary
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
Ikappa B-zeta variant 3|IkappaB-zeta|molecule possessing ankyrin repeats induced by lipopolysaccharide
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Interactome
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Disease
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