PDF purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human PDF protein.
Immunogen
PDF (AAH19912.1, 1 a.a. ~ 243 a.a) full-length human protein.
Sequence
MARLWGALSLRPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWRHLRRLVLGPPEPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVGLSAPQLGVPRQVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRVLDSRLVTFPEGCESVAGFLACVPRFQAVQISGLDPNGEQVVWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (77); Rat (73)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PDF expression in transfected 293T cell line (H00064146-T02) by PDF MaxPab polyclonal antibody.
Lane 1: PDF transfected lysate(26.73 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PDF
Entrez GeneID
64146GeneBank Accession#
BC019912Protein Accession#
AAH19912.1Gene Name
PDF
Gene Alias
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Gene Description
peptide deformylase (mitochondrial)
Gene Ontology
HyperlinkGene Summary
Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells. [provided by RefSeq
Other Designations
peptide deformylase|peptide deformylase-like protein
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Interactome
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Disease
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