Immunoprecipitation of ELAC2 transfected lysate using anti-ELAC2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with ELAC2 purified MaxPab mouse polyclonal antibody (B01P) (H00060528-B01P).
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
elaC homolog 2,hereditary prostate cancer,putative prostate cancer susceptibility protein,tRNA Z (long form)