Western blot analysis of TGIF2 over-expressed 293 cell line, cotransfected with TGIF2 Validated Chimera RNAi ( Cat # H00060436-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with TGIF2 monoclonal antibody (M01), clone 4C10 (Cat # H00060436-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly. [provided by RefSeq
5'-TG-3' interacting factor 2,OTTHUMP00000030848,OTTHUMP00000030849,TGF(beta)-induced transcription factor 2,TGFB-induced factor 2 (TALE family homeobox),homeobox protein TGIF2,transcription growth factor-beta-induced factor 2