ALOXE3 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
ALOXE3 transfected lysate.
Western Blot
Lane 1: ALOXE3 transfected lysate ( 78.32 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ALOXE3 full-length
Host
Human
Theoretical MW (kDa)
78.32
Interspecies Antigen Sequence
Mouse (88); Rat (87)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ALOXE3 antibody (H00059344-B01) by Western Blots.
SDS-PAGE Gel
ALOXE3 transfected lysate.
Western Blot
Lane 1: ALOXE3 transfected lysate ( 78.32 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ALOXE3
Entrez GeneID
59344GeneBank Accession#
BC101938.1Protein Accession#
AAI01939.1Gene Name
ALOXE3
Gene Alias
E-LOX, MGC119694, MGC119695, MGC119696, eLOX3
Gene Description
arachidonate lipoxygenase 3
Gene Ontology
HyperlinkGene Summary
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene
Other Designations
epidermal lipoxygenase|lipoxygenase-3
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Interactome
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Disease
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