ALOXE3 (Human) IP-WB Antibody Pair
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More Files
- More Functions
Immunoprecipitation of ALOXE3 transfected lysate using rabbit polyclonal anti-ALOXE3 and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-ALOXE3.
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Specification
Product Description
This IP-WB antibody pair set comes with one antibody for immunoprecipitation and another to detect the precipitated protein in western blot.
Reactivity
Human
Interspecies Antigen Sequence
Mouse (88); Rat (87)
Quality Control Testing
Immunoprecipitation-Western Blot (IP-WB)
Immunoprecipitation of ALOXE3 transfected lysate using rabbit polyclonal anti-ALOXE3 and Protein A Magnetic Bead (U0007), and immunoblotted with mouse purified polyclonal anti-ALOXE3.
Supplied Product
Antibody pair set content:
1. Antibody pair for IP: rabbit polyclonal anti-ALOXE3 (300 ul)
2. Antibody pair for WB: mouse purified polyclonal anti-ALOXE3 (50 ug)
Storage Instruction
Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
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Applications
Immunoprecipitation-Western Blot
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Gene Info — ALOXE3
Entrez GeneID
59344Gene Name
ALOXE3
Gene Alias
E-LOX, MGC119694, MGC119695, MGC119696, eLOX3
Gene Description
arachidonate lipoxygenase 3
Gene Ontology
HyperlinkGene Summary
This gene is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin. This gene is part of a cluster of lipoxygenase genes on 17p13.1. Mutations in this gene result in nonbullous congenital ichthyosiform erythroderma (NCIE). Multiple transcript variants encoding different isoforms have been found for this gene
Other Designations
epidermal lipoxygenase|lipoxygenase-3
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Interactome
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Disease
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