Western blot analysis of MS4A7 over-expressed 293 cell line, cotransfected with MS4A7 Validated Chimera RNAi ( Cat # H00058475-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with MS4A7 monoclonal antibody (M06), clone 2D3 (Cat # H00058475-M06 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq
CD20/Fc-epsilon-RI-beta family member 4,four-span transmembrane protein 2,high affinity immunoglobulin epsilon receptor beta subunit