PTBP2 monoclonal antibody (M01), clone 2D10-B2
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More Files
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Western Blot (Tissue lysate)
PTBP2 monoclonal antibody (M01), clone 2D10-B2. Western Blot analysis of PTBP2 expression in human brain membrane (lane 1) and human brain cortex (lane 2).
Western Blot (Cell lysate)
PTBP2 monoclonal antibody (M01), clone 2D10-B2 Western Blot analysis of PTBP2 expression in IMR-32 ( Cat # L008V1 ).
Western Blot detection against Immunogen (84.26 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant PTBP2.
Immunogen
PTBP2 (AAH16582, 1 a.a. ~ 532 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MDGIVTEVAVGVKRGSDELLSGSVLSSPNSNMSSMVVTANGNDSKKFKGEDKMDGAPSRVLHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKTDNTLNQRAQAVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPDLPSGDGQPALDPAIAAAFAKETSLLAVPGALSPLAIPNAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQALIDLHNYNLGENHHLRVSFSKSTI
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (84.26 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PTBP2 monoclonal antibody (M01), clone 2D10-B2. Western Blot analysis of PTBP2 expression in human brain membrane (lane 1) and human brain cortex (lane 2).Western Blot (Cell lysate)
PTBP2 monoclonal antibody (M01), clone 2D10-B2 Western Blot analysis of PTBP2 expression in IMR-32 ( Cat # L008V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — PTBP2
Entrez GeneID
58155GeneBank Accession#
BC016582Protein Accession#
AAH16582Gene Name
PTBP2
Gene Alias
FLJ34897, PTB, PTBLP, brPTB, nPTB, nPTB5, nPTB6, nPTB7, nPTB8
Gene Description
polypyrimidine tract binding protein 2
Omim ID
608449Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds to the intronic cluster of RNA regulatory elements, downstream control sequence (DCS). It is implicated in controlling the assembly of other splicing-regulatory proteins. This protein is very similar to the polypyrimidine tract binding protein but it is expressed primarily in the brain. [provided by RefSeq
Other Designations
OTTHUMP00000012411|PTB-like|neural polypyrimidine tract binding protein|splicing regulator
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Interactome
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Disease
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Publication Reference
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The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells.
Lin JC, Lee YC, Liang YC, Fann YC, Johnson KR, Lin YJ.
Scientific Reports 2017 Mar; 7:44204.
Application：WB-Tr, Human, HCT-8 cells.
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The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells.
Liang YC, Lin WC, Lin YJ, Lin JC.
Oncotarget 2015 Nov; 6(35):38046.
Application：WB-Ce, WB-Ti, Human, Colorectal cancer tissues and HCT-8, HCT-116, Colo205 cells.
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Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping.
Xue Y, Zhou Y, Wu T, Zhu T, Ji X, Kwon YS, Zhang C, Yeo G, Black DL, Sun H, Fu XD, Zhang Y.
Molecular Cell 2009 Dec; 36(6):996.
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The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells.
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