HAMP polyclonal antibody (A01)
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More Files
- More Functions
Western Blot detection against Immunogen (32.71 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length recombinant HAMP.
Immunogen
HAMP (AAH20612, 25 a.a. ~ 84 a.a) full-length recombinant protein with GST tag.
Sequence
SVFPQQTGQLAELQPQDRAGARASWMPMFQRRRRRDTHFPICIFCCGCCHRSKCGMCCKT
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (32.71 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — HAMP
Entrez GeneID
57817GeneBank Accession#
BC020612Protein Accession#
AAH20612Gene Name
HAMP
Gene Alias
HEPC, HEPCIDIN, HFE2B, LEAP-1, LEAP1, PLTR
Gene Description
hepcidin antimicrobial peptide
Gene Ontology
HyperlinkGene Summary
The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure. [provided by RefSeq
Other Designations
liver-expressed antimicrobial peptide|putative liver tumor regressor
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Interactome
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Disease
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