Western blot analysis of TRIB3 over-expressed 293 cell line, cotransfected with TRIB3 Validated Chimera RNAi ( Cat # H00057761-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with TRIB3 monoclonal antibody (M03) clone 1H2 (Cat # H00057761-M03 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. [provided by RefSeq
neuronal cell death inducible putative kinase,p65-interacting inhibitor of NF-kappaB,tribbles 3