GBA3 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human GBA3 partial ORF ( NP_066024, 402 a.a. - 468 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
KAIQLDKVNLQVYCAWSLLDNFEWNQGYSSRFGLFHVDFEDPARPRVPYTSAKEYAKIIRNNGLEAH
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
33.11
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — GBA3
Entrez GeneID
57733GeneBank Accession#
NM_020973Protein Accession#
NP_066024Gene Name
GBA3
Gene Alias
CBGL1, GLUC, KLrP, MGC104276, MGC126878
Gene Description
glucosidase, beta, acid 3 (cytosolic)
Omim ID
606619Gene Ontology
HyperlinkGene Summary
GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]). GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]).[supplied by OMIM
Other Designations
cytosolic beta-glucosidase|klotho-related protein
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Pathway
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