WDR19 purified MaxPab mouse polyclonal antibody (B01P)
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse polyclonal antibody raised against a full-length human WDR19 protein.
Immunogen
WDR19 (AAH32578.1, 1 a.a. ~ 437 a.a) full-length human protein.
Sequence
MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSEINLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGGEDKMITVSNQEGDTIRQTQVRSEPSNMQFFLMKMDDRTSAAESMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCYNWYGDGRIMIGFSCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCGDNCIKIQDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKIERYGVSGNSSQYLPSF
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (85); Rat (85)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
-
Applications
Western Blot (Transfected lysate)
Western Blot analysis of WDR19 expression in transfected 293T cell line by WDR19 MaxPab polyclonal antibody.
Lane 1: WDR19 transfected lysate(48.07 KDa).
Lane 2: Non-transfected lysate.
-
Gene Info — WDR19
Entrez GeneID
57728GeneBank Accession#
BC032578Protein Accession#
AAH32578.1Gene Name
WDR19
Gene Alias
FLJ23127, KIAA1638, ORF26, PWDMP
Gene Description
WD repeat domain 19
Omim ID
608151Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined. [provided by RefSeq
Other Designations
WD repeat membrane protein PWDMP
-
Interactome
-
Publication Reference
-
Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa.
Nguyen TT, Hull S, Roepman R, van den Born LI, Oud MM, de Vrieze E, Hetterschijt L, Letteboer SJF, van Beersum SEC, Blokland EA, Yntema HG, Cremers FPM, van der Zwaag PA, Arno G, van Wijk E, Webster AR, Haer-Wigman L.
Amino Acids 2017 Sep; 54(9):624.
Application:IF, Human, Human fibroblasts from patients with retinitis pigmentosa (RP).
-
ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.
Chaya T, Omori Y, Kuwahara R, Furukawa T.
The EMBO Journal 2014 Jun; 33(11):1227.
Application:IF, Mouse, MEFs.
-
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies.
Ashe A, Butterfield NC, Town L, Courtney AD, Cooper AN, Ferguson C, Barry R, Olsson F, Liem KF Jr, Parton RG, Wainwright BJ, Anderson KV, Whitelaw E, Wicking C.
Human Molecular Genetics 2012 Apr; 21(8):1808.
Application:IF, Mouse, MEFs.
-
Ciliopathies with Skeletal Anomalies and Renal Insufficiency due to Mutations in the IFT-A Gene WDR19.
Bredrup C, Saunier S, Oud MM, Fiskerstrand T, Hoischen A, Brackman D, Leh SM, Midtbo M, Filhol E, Bole-Feysot C, Nitschke P, Gilissen C, Haugen OH, Sanders JS, Stolte-Dijkstra I, Mans DA, Steenbergen EJ, Hamel BC, Matignon M, Pfundt R, Jeanpierre C, Boman H, Rodahl E, Veltman JA, Knappskog PM, Knoers NV, Roepman R, Arts HH.
American Journal of Human Genetics 2011 Nov; 89(5):634.
Application:IF, Human, Human fibroblasts.
-
Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com