SH3RF1 polyclonal antibody (A01)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant SH3RF1.
Immunogen
SH3RF1 (NP_065921, 790 a.a. ~ 888 a.a) partial recombinant protein with GST tag.
Sequence
LAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (96)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — SH3RF1
Entrez GeneID
57630GeneBank Accession#
NM_020870Protein Accession#
NP_065921Gene Name
SH3RF1
Gene Alias
FLJ21602, KIAA1494, POSH, RNF142, SH3MD2
Gene Description
SH3 domain containing ring finger 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq
Other Designations
SH3 multiple domains 2|plenty of SH3 domains|plenty of SH3s|ring finger protein 142
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Interactome
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Disease
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Publication Reference
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Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model.
Wilhelm M, Xu Z, Kukekov NV, Gire S, Greene LA.
The Journal of Biological Chemistry 2006 Nov; 282(2):1288.
Application:WB, Human, HEK 293.
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Proapoptotic Nix activates the JNK pathway by interacting with POSH and mediates death in a Parkinson disease model.
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