Immunoprecipitation of RPTOR transfected lysate using anti-RPTOR MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with RPTOR purified MaxPab mouse polyclonal antibody (B01P) (H00057521-B01P).
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats,regulatory associated protein of mTOR