XPO5 monoclonal antibody (M01), clone 2C5-1B3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant XPO5.
Immunogen
XPO5 (AAH00129, 1 a.a. ~ 280 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MRLSQKWQVINQRSLLCGEDEAADENPESQEMLEEQLVRMLTREVMDLITVCCVSKKGADHSSAPPADGDDEEMMATEVTPSAMAELTDLGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTLLADAVTWLFTSVLKGLQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAVMEQIPEIQKDSLDQFDCKLLNPSLQKVADKRRKDQFKRLIAGCIGKPLGEQFRKEVHIKNLPSLFKKTKPMLETEVLDNDGGGLATIFEP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (87); Rat (87)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (56.54 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
XPO5 monoclonal antibody (M01), clone 2C5-1B3 Western Blot analysis of XPO5 expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Transfected lysate)
Western Blot analysis of XPO5 expression in transfected 293T cell line by XPO5 monoclonal antibody (M01), clone 2C5-1B3.
Lane 1: XPO5 transfected lysate(136.3 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Immunoprecipitation
Immunoprecipitation of XPO5 transfected lysate using anti-XPO5 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with XPO5 MaxPab rabbit polyclonal antibody.Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged XPO5 is approximately 1ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to XPO5 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — XPO5
Entrez GeneID
57510GeneBank Accession#
BC000129Protein Accession#
AAH00129Gene Name
XPO5
Gene Alias
FLJ14239, FLJ32057, FLJ45606, KIAA1291
Gene Description
exportin 5
Omim ID
607845Gene Ontology
HyperlinkGene Summary
Exportin-5 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments.[supplied by OMIM
Other Designations
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Interactome
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Disease
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Publication Reference
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An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
Clancy JW, Zhang Y, Sheehan C, D'Souza-Schorey C.
Nature Cell Biology 2019 Jul; 21(7):856.
Application:IF, Human, LOX melanoma cells.
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Knock-down of core proteins regulating microRNA biogenesis has no effect on sensitivity of lung cancer cells to ionizing radiation.
Surova O, Akbar NS, Zhivotovsky B.
PLoS One 2012 Mar; 7(3):e33134.
Application:WB-Ce, Human, Human lung cancer cell lines.
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MicroRNAs are expressed and processed by human primary macrophages.
Luers AJ, Loudig OD, Berman JW.
Cellular Immunology 2010 Mar; 263(1):1.
Application:WB, Human, Macrophages, HeLa cells.
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An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
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