MTUS1 monoclonal antibody (M01), clone 1C7
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant MTUS1.
Immunogen
MTUS1 (AAH33842, 1 a.a. ~ 240 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MQLQEQFDNLNAAHETSKLEIEASHSEKLELLTKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMGKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (92)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (52.03 kDa).
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
MTUS1 monoclonal antibody (M01), clone 1C7. Western Blot analysis of MTUS1 expression in human ovarian cancer.Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged MTUS1 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — MTUS1
Entrez GeneID
57509GeneBank Accession#
BC033842Protein Accession#
AAH33842Gene Name
MTUS1
Gene Alias
ATIP, DKFZp586D1519, DKFZp686F20243, FLJ14295, KIAA1288, MP44, MTSG1
Gene Description
mitochondrial tumor suppressor 1
Omim ID
609589Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which contains a C-terminal domain able to interact with the angiotension II (AT2) receptor and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and partcipates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. [provided by RefSeq
Other Designations
AT2 receptor-interacting protein|erythroid differentiation-related|mitochondrial tumor suppressor gene 1|transcription factor MTSG1
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Interactome
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Disease
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Publication Reference
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Combinatorial expression of microtubule-associated EB1 and ATIP3 biomarkers improves breast cancer prognosis.
Rodrigues-Ferreira S, Nehlig A, Monchecourt C, Nasr S, Fuhrmann L, Lacroix-Triki M, Garberis I, Scott V, Delaloge S, Pistilli B, Vielh P, Dubois T, Vincent-Salomon A, André F, Nahmias C.
Breast Cancer Res Treat 2018 Oct; [Epub].
Application:IHC-P, Human, Human breast cancer.
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Angiotensin II type 2 receptor-interacting protein 3a suppresses proliferation, migration and invasion in tongue squamous cell carcinoma via the extracellular signal-regulated kinase-Snai2 pathway.
Zhao T, He Q, Liu Z, Ding X, Zhou X, Wang A.
Oncology Letters 2016 Jan; 11:340.
Application:WB, Human, TSCC cells.
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Genetic and functional characterization of clonally derived adult human brown adipocytes.
Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S.
Nature Medicine 2015 Apr; 21(4):389.
Application:WB-Tr, WB-Ti, Human, Mouse, Adipocyte, Supraclavicular adipose tissues.
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Loss of MTUS1/ATIP expression is associated with adverse outcome in advanced bladder carcinomas: data from a retrospective study.
Rogler A, Hoja S, Giedl J, Ekici AB, Wach S, Taubert H, Goebell PJ, Wullich B, Stockle M, Lehmann J, Petsch S, Hartmann A, Stoehr R.
BMC Cancer 2014 Mar; 14:214.
Application:IHC-P, WB-Ti, Human, Papillary bladder carcinomas, HCV29, RT112, J82, BFTC905, RT4, UROtsa, LNCaP cells.
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Expression and role of the angiotensin II AT2 receptor in human prostate tissue: In search of a new therapeutic option for prostate cancer.
Guimond MO, Battista MC, Nikjouitavabi F, Carmel M, Barres V, Doueik AA, Fazli L, Gleave M, Sabbagh R, Gallo-Payet N.
The Prostate 2013 Jul; 73(10):1057.
Application:IHC, Human, Prostatic tissues.
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Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma.
Ding X, Zhang N, Cai Y, Li S, Zheng C, Jin Y, Yu T, Wang A, Zhou X.
Molecular Oncology 2012 Feb; 6(1):73.
Application:IHC-P, WB-Ti, Human, Tongue, Oral tongue squamous cell carcinoma.
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LOH and copy neutral LOH (cnLOH) act as alternative mechanism in sporadic colorectal cancers with chromosomal and microsatellite instability.
Melcher R, Hartmann E, Zopf W, Herterich S, Wilke P, Muller L, Rosler E, Kudlich T, Al-Taie O, Rosenwald A, Katzenberger T, Scholtka B, Seibold S, Rogoll D, Scheppach W, Scheurlen M, Luhrs H.
Carcinogenesis 2011 Apr; 32(4):636.
Application:IHC, Human, Colorectal cancer tumors.
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8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis.
Rodrigues-Ferreira S, Di Tommaso A, Dimitrov A, Cazaubon S, Gruel N, Colasson H, Nicolas A, Chaverot N, Molinie V, Reyal F, Sigal-Zafrani B, Terris B, Delattre O, Radvanyi F, Perez F, Vincent-Salomon A, Nahmias C.
PLoS One 2009 Oct; 4(10):e7239.
Application:IF, IHC-P, WB-Tr, Human, Breast cancer, MDA-MB-231 cells.
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Combinatorial expression of microtubule-associated EB1 and ATIP3 biomarkers improves breast cancer prognosis.
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