VISA purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
VISA MaxPab polyclonal antibody. Western Blot analysis of VISA expression in human placenta.
Western Blot (Transfected lysate)
Western Blot analysis of VISA expression in transfected 293T cell line (H00057506-T01) by VISA MaxPab polyclonal antibody.
Lane 1: VISA transfected lysate(59.4 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human VISA protein.
Immunogen
VISA (AAH44952.1, 1 a.a. ~ 540 a.a) full-length human protein.
Sequence
MPFAEDKTYKYICRNFSNFCNVDVVEILPYLPCLTARDQDRLRATCTLSGNRDTLWHLFNTLQRRPGWVEYFIAALRGCELVDLADEVASVYESYQPRTSDRPPDPLEPPSLPAERPGPPTPAAAHSIPYNSCREKEPSYPMPVQETQAPESPGENSEQALQTLSPRAIPRNPDGGPLESSSDLAALSPLTSSGHQEKDTELGSTHTAGATSSLTPSRGPVSPSVSFQPLARSTPRASRLPGPTGSVVSTGTSFSSSSPGLASAGAAEGKQGAESDQAEPIICSSGAEAPANSLPSKVPTTLMPVNTVALKVPANPASVSTVPSKLPTSSKPPGAVPSNALTNPAPSKLPINSTRAGMVPSKVPTSMVLTKVSASTVPTDGSSRNEETPAAPTPAGATGGSSAWLDSSFENRGLGSELSKPGVLASQVDSPFSGCFEDLAISASTSLGMGPCHGPEENEYKSEGTFGIHVAENPSIQLLEGNPGPPADPDGGPRPQADRKFQEREVPCHRPSPGALWLQVAVTGVLVVTLLVVLYRRRLH
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (50); Rat (48)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
VISA MaxPab polyclonal antibody. Western Blot analysis of VISA expression in human placenta.Western Blot (Transfected lysate)
Western Blot analysis of VISA expression in transfected 293T cell line (H00057506-T01) by VISA MaxPab polyclonal antibody.
Lane 1: VISA transfected lysate(59.4 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — VISA
Entrez GeneID
57506GeneBank Accession#
BC044952.1Protein Accession#
AAH44952.1Gene Name
VISA
Gene Alias
CARDIF, DKFZp547C224, DKFZp666M015, FLJ27482, FLJ35386, FLJ38051, FLJ41962, IPS-1, IPS1, KIAA1271, MAVS, MGC3260
Gene Description
virus-induced signaling adapter
Omim ID
609676Gene Ontology
HyperlinkGene Summary
Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM
Other Designations
CARD adapter inducing interferon-beta|OTTHUMP00000030141|interferon-beta promoter stimulator protein 1|mitochondrial anti-viral signaling protein|virus-induced signaling adapter variant 1b|virus-induced signaling adaptor variant 1a
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Interactome
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Disease
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