CHMP1B (Human) Recombinant Protein (P01)
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Specification
Product Description
Human CHMP1B full-length ORF ( NP_065145.2, 1 a.a. - 199 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
48.5
Interspecies Antigen Sequence
Mouse (97); Rat (99)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CHMP1B
Entrez GeneID
57132GeneBank Accession#
NM_020412.3Protein Accession#
NP_065145.2Gene Name
CHMP1B
Gene Alias
C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2
Gene Description
chromatin modifying protein 1B
Omim ID
606486Gene Ontology
HyperlinkGene Summary
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM
Other Designations
vacuolar protein sorting 46-2
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Interactome
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Pathway
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