CHMP1B polyclonal antibody (A01)
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More Files
- More Functions
Western Blot detection against Immunogen (32.16 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant CHMP1B.
Immunogen
CHMP1B (NP_065145, 145 a.a. ~ 199 a.a) partial recombinant protein with GST tag.
Sequence
PQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97); Rat (99)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (32.16 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — CHMP1B
Entrez GeneID
57132GeneBank Accession#
NM_020412Protein Accession#
NP_065145Gene Name
CHMP1B
Gene Alias
C10orf2, C18-ORF2, C18orf2, CHMP1.5, Vps46-2
Gene Description
chromatin modifying protein 1B
Omim ID
606486Gene Ontology
HyperlinkGene Summary
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM
Other Designations
vacuolar protein sorting 46-2
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Interactome
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Pathway
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Disease
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Publication Reference
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MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis.
Lee S, Chang J, Renvoisé B, Tipirneni A, Yang S, Blackstone C.
Molecular Biology of the Cell 2012 Nov; 23(22):4347.
Application：IF, Human, HeLa cells.
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Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B.
Yang D, Rismanchi N, Renvoise B, Lippincott-Schwartz J, Blackstone C, Hurley JH.
Nature Structural & Molecular Biology 2008 Dec; 15(12):1278.
Application：WB, IF, Human, HeLa cells.
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MITD1 is recruited to midbodies by ESCRT-III and participates in cytokinesis.
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