C12orf5 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human C12orf5 full-length ORF ( NP_065108.1, 1 a.a. - 270 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQAAAAGIFLNNVKFTHAFSSDLMRTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALSELRAMAKAAREECPVFTPPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNCLETSLAEIFPLGKNHSSKVNSDSGIPGLAASVLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPNTGMSLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
56.5
Interspecies Antigen Sequence
Mouse (72)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — C12orf5
Entrez GeneID
57103GeneBank Accession#
NM_020375.2Protein Accession#
NP_065108.1Gene Name
C12orf5
Gene Alias
TIGAR
Gene Description
chromosome 12 open reading frame 5
Omim ID
610775Gene Ontology
HyperlinkGene Summary
This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq
Other Designations
TP53-induced glycolysis and apoptosis regulator|transactivated by NS3TP2 protein
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