POLE4 polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant POLE4.
Immunogen
POLE4 (NP_063949, 31 a.a. ~ 117 a.a) partial recombinant protein with GST tag.
Sequence
TSVPGARLSRLPLARVKALVKADPDVTLAGQEAIFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (96); Rat (96)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (35.68 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — POLE4
Entrez GeneID
56655GeneBank Accession#
NM_019896Protein Accession#
NP_063949Gene Name
POLE4
Gene Alias
p12
Gene Description
polymerase (DNA-directed), epsilon 4 (p12 subunit)
Omim ID
607269Gene Ontology
HyperlinkGene Summary
POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM
Other Designations
DNA polymerase epsilon p12 subunit|DNA polymerase epsilon subunit 4
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Interactome
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Pathway
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Publication Reference
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Polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature ("FILS syndrome").
Pachlopnik Schmid J, Lemoine R, Nehme N, Cormier-Daire V, Revy P, Debeurme F, Debré M, Nitschke P, Bole-Feysot C, Legeai-Mallet L, Lim A, de Villartay JP, Picard C, Durandy A, Fischer A, de Saint Basile G.
The Journal of Experimental Medicine 2012 Dec; 209(13):2323.
Application:WB-Ce, Human, Lymphoblasts.
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Polymerase ε1 mutation in a human syndrome with facial dysmorphism, immunodeficiency, livedo, and short stature ("FILS syndrome").
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