BCCIP 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-BCCIP full-length
Host
Human
Theoretical MW (kDa)
34.65
Interspecies Antigen Sequence
Mouse (75); Rat (77)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-BCCIP antibody (H00056647-B01) by Western Blots.
SDS-PAGE Gel
BCCIP transfected lysate.
Western Blot
Lane 1: BCCIP transfected lysate ( 34.54 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — BCCIP
Entrez GeneID
56647GeneBank Accession#
BC009771Protein Accession#
AAH09771Gene Name
BCCIP
Gene Alias
TOK-1, TOK1
Gene Description
BRCA2 and CDKN1A interacting protein
Gene Ontology
HyperlinkGene Summary
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
BCCIPalpha|BCCIPbeta|BRCA2 and CDKN1A-interacting protein|BRCA2 and Cip1/p21 interacting protein|OTTHUMP00000020714|OTTHUMP00000020715|OTTHUMP00000020716|TOK-1alpha|TOK-1beta|cdk inhibitor p21 binding protein|p21- and CDK-associated protein 1
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Interactome
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Disease
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