CTPS2 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human CTPS2 peptide using ARM Technology.
Immunogen
A synthetic peptide of human CTPS2 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human CTPS2 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — CTPS2
Entrez GeneID
56474GeneBank Accession#
CTPS2Gene Name
CTPS2
Gene Alias
DKFZp686C17207, FLJ43358, MGC32997
Gene Description
CTP synthase II
Omim ID
300380Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq
Other Designations
CTP synthetase isoform|CTP synthetase type 2|OTTHUMP00000022985|OTTHUMP00000022986|UTP-ammonia ligase|cytidine 5'-triphosphate synthetase 2|cytidine triphosphate synthase II
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Interactome
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Pathway
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