Products

Western Blot (Transfected lysate)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

CTPS2

Gene Alias

DKFZp686C17207, FLJ43358, MGC32997

Gene Description

CTP synthase II

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq

Other Designations

CTP synthetase isoform|CTP synthetase type 2|OTTHUMP00000022985|OTTHUMP00000022986|UTP-ammonia ligase|cytidine 5'-triphosphate synthetase 2|cytidine triphosphate synthase II