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PCDHGA2 Validated Chimera RNAi

  • Catalog # : H00056113-R01V
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  • Specification
  • Product Description:
  • Homo sapiens protocadherin gamma subfamily A, 2 (PCDHGA2), transcript variant 1, mRNA.
  • Reactivity:
  • Human
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_018915
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown (Antibody validated)
  • RNAi Knockdown (Antibody validated)
  • Western blot analysis of PCDHGA2 over-expressed 293 cell line, cotransfected with PCDHGA2 Validated Chimera RNAi ( Cat # H00056113-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with PCDHGA2 monoclonal antibody (M01), clone 2A7 (Cat # H00056113-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
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  • Application Image
  • RNAi Knockdown (Antibody validated)
  • RNAi Knockdown (Antibody validated)
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  • Gene Information
  • Gene Name:
  • PCDHGA2
  • Gene Alias:
  • PCDH-GAMMA-A2
  • Gene Description:
  • protocadherin gamma subfamily A, 2
  • Gene Summary:
  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq
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