PCDHGB2 monoclonal antibody (M02), clone 6E9
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant PCDHGB2.
Immunogen
PCDHGB2 (NP_061746, 94 a.a. ~ 199 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
QICGKQPLCVLDFDTVAENPLNIFYIAVIVQDINDNTPLFKQTKINLKIGESTKPGTTFPLDPALDSDVGPNSLQRYHLNDNEYFDLAEKQTPDGRKYPELILKHS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (80)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.4 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PCDHGB2 expression in transfected 293T cell line by PCDHGB2 monoclonal antibody (M02), clone 6E9.
Lane 1: PCDHGB2 transfected lysate (Predicted MW: 88.4 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged PCDHGB2 is 0.1 ng/ml as a capture antibody.ELISA
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Gene Info — PCDHGB2
Entrez GeneID
56103GeneBank Accession#
NM_018923Protein Accession#
NP_061746Gene Name
PCDHGB2
Gene Alias
MGC126854, PCDH-GAMMA-B2
Gene Description
protocadherin gamma subfamily B, 2
Omim ID
606300Gene Ontology
HyperlinkGene Summary
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq
Other Designations
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